Research going back more than 30 years has confirmed that calcitonin gene-related peptide (CGRP) plays a major role in migraine. However, this work has revealed little about the locations of the protein’s migraine activity in the body.
That was until researchers at the University of Texas at Dallas, who carried out a preclinical investigation in rats and mice, pinpointed where certain pain-related CGRP activity takes place in the body. They also found that this particular activity occurs only in females.